Product InformationRegistration Status: Active
EXODIN TABLET 180MG is approved to be sold in Singapore with effective from 2014-08-18. It is marketed by PHARMAZEN MEDICALS PTE LTD, with the registration number of SIN14591P.
This product contains Fexofenadine 180mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.
This product is manufactured by Medreich LTD in INDIA.
It is a has been granted the exemption for supply without a presciption if it met certain criteria.
Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.
For management of Seasonal allergic rhinitis
Mechanism of Action
Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Fexofenadine exhibits no anticholinergic, antidopaminergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects.
- Approximately 5% of the total dose is metabolized, by cytochrome P450 3A4 and by intestinal microflora.
Side effects include dizziness, drowsiness, and dry mouth.
4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid | Carboxyterfenadine | Fexofenadine | Terfenadine acid metabolite | Terfenadine carboxylate | Terfenadine-COOH | Fexofenadine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.