Product Information
Registration Status: ActiveSIN07568P
FAMOTIN TABLET 40mg is approved to be sold in Singapore with effective from 1993-06-12. It is marketed by DRUG HOUSES OF AUSTRALIA PTE LTD, with the registration number of SIN07568P.
This product contains Famotidine 40mg in the form of TABLET. It is approved for ORAL use.
This product is manufactured by PT ACTAVIS INDONESIA in INDONESIA REP OF.
It is a has been granted the exemption for supply without a presciption if it met certain criteria.
Product Reference
Important Note: For generic product, the SPC/PIL provided may not be brand specific.
{{/items}} {{^items}}Description
A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. [PubChem]
Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Mechanism of Action
Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.
Pharmacokinetics
- Absorption
- The bioavailability of oral doses is 40-45%.
- Distribution
- Metabolism
- Hepatic.
- Elimination
Clearance
* renal cl=250-450 mL/min
Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Active Ingredient/Synonyms
(1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide | 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide | 3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine | Famotidina | Famotidinum | N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide | Famotidine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.