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MORIDONE TABLET 10mg

Product Information

Registration Status: Active

SIN11125P

MORIDONE TABLET 10mg is approved to be sold in Singapore with effective from 1999-09-25. It is marketed by SINGAPORE PHARMACEUTICAL PTE LTD, with the registration number of SIN11125P.

This product contains Domperidone 10mg in the form of TABLET. It is approved for ORAL use.

This product is manufactured by PRIME PHARMACEUTICAL SDN BHD in MALAYSIA.

It is a has been granted the exemption for supply without a presciption if it met certain criteria.

Reclassified Info

Product Reference
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Description

A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. [PubChem]

Indication

For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.

Mechanism of Action

Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting

Pharmacokinetics

Absorption
Fast
Distribution
Metabolism
Elimination

Toxicity

Side effects include galactorrhea, gynecomastia, or menstrual irregularities.

Active Ingredient/Synonyms

1-(3-(4-(5-chloro-2-oxo-2,3-Dihydrobenzo[D]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[D]imidazol-2(3H)-one | 5-chloro-1-(1-(3-(2-oxo-1-Benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone | 5-chloro-1-(1-(3-(2-oxo-2,3-Dihydrobenzo[D]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[D]imidazol-2(3H)-one | 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one | Domperidona | Domperidonum | Domperidone |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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