HSA Reclassified Drug | Exemptions For Supply of Adapalene Without Prescription


Eligible Active Ingredient: Adapalene. As a topical preparation not exceeding 0.1%
With Effective From: 31-Mar-16
Indication Permitted: Treatment of acne vulgaris
Maximum Daily Dose: Apply to the affected areas once daily
Maximum Supply per Transaction: 30g
Minimum Age of User: 12 years
Patient Information Leaflet from HSA/PSS: Download PIL (Link to HSA website)

Mechanism of Action of Adapalene

Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and retinoid X receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

Additional Information of Adapalene

Pharmacology Class: Anti-Acne Preparations For Topical Use
Therapeutic Class: Anti-Acne Preparations
Chemical Class: Retinoids For Topical Use In Acne
Synonyms: 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid | Adaferin | Adapaleno | Adapalenum | Differine

Show All HSA-registered therapeutic products granted exemption to supply without prescription


  1. Health Science Authority of Singapore – Reclassified POM
  2. Drugbank

HSA-Registered Products Containing Adapalene As a topical preparation not exceeding 0.1%

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This list is not exhaustive. HSA collaborates with Pharmaceurical Society of Singapore (PSS) to review the appropriate use of therapeutic products in the community from time to time. Hence, HSA may enable the supply of a Prescription Only Medicine (POM) by pharmacists without a prescription, upon review that the product can be used in a safe and effective manner under the supervision of a pharmacist. This can be effected through legislative mechanisms in the absence of an application made by the product registrant to reclassify the therapeutic product, subject to to conditions including indication, strength, maximum daily dose, maximum supply quantity, and age restriction.