Criteria
| Eligible Active Ingredient: | Desonide. As a topical cream or lotion preparation containing not more than 0.05% w/w |
| With Effective From: | 1-Jan-13 |
| Indication Permitted: | Treatment of redness, swelling and itching that is associated with minor skin ailments such as eczema. |
| Maximum Daily Dose: | 2 to 3 times daily depending on severity. |
| Maximum Supply per Transaction: | 15g (cream) or 60ml (lotion) |
| Minimum Age of User: | 18 years |
| Patient Information Leaflet from HSA/PSS: | Download PIL (Link to HSA website) |
Mechanism of Action of Desonide
Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Additional Information of Desonide
| Pharmacology Class: | Corticosteroids, Plain |
| Therapeutic Class: | Corticosteroids, Dermatological Preparations |
| Chemical Class: | Corticosteroids, Moderately Potent (Group II) |
| Synonyms: | 11beta,21-Dihydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione | 11beta,21-Dihydroxy-16alpha,17-isopropylidenedioxypregna-1,4-diene-3,20-dione | 11beta,21-Dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione | 16alpha-Hydroxyprednisole-16,17-acetonide | 16alpha-Hydroxyprednisolone-16alpha,17-acetonide | 16alpha,17alpha-Isopropylidenedioxyprednisolone | Desfluorotriamcinolone acetonide | Desonida | Desonidum |
Show All HSA-registered therapeutic products granted exemption to supply without prescription
References
HSA-Registered Products Containing Desonide As a topical cream or lotion preparation containing not more than 0.05% w/w
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This list is not exhaustive. HSA collaborates with Pharmaceurical Society of Singapore (PSS) to review the appropriate use of therapeutic products in the community from time to time. Hence, HSA may enable the supply of a Prescription Only Medicine (POM) by pharmacists without a prescription, upon review that the product can be used in a safe and effective manner under the supervision of a pharmacist. This can be effected through legislative mechanisms in the absence of an application made by the product registrant to reclassify the therapeutic product, subject to to conditions including indication, strength, maximum daily dose, maximum supply quantity, and age restriction.