HSA Reclassified Drug | Exemptions For Supply of Esomeprazole Without Prescription


Eligible Active Ingredient: Esomeprazole. As an oral solid preparation not exceeding 20mg
With Effective From: 1-Dec-16
Indication Permitted: Relief of heartburn symptoms associated with acid reflux
Maximum Daily Dose: 20mg
Maximum Supply per Transaction: 2 weeks
Minimum Age of User: 18 years
Patient Information Leaflet from HSA/PSS: Download PIL (Link to HSA website)

Mechanism of Action of Esomeprazole

Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.

Additional Information of Esomeprazole

Pharmacology Class: Drugs For Peptic Ulcer And Gastro-Oesophageal Reflux Disease (Gord)
Therapeutic Class: Drugs For Acid Related Disorders
Chemical Class: Proton Pump Inhibitors
Synonyms: (−)-omeprazole | (S)-(−)-omeprazole | (S)-omeprazole | Esomeprazol | Ésoméprazole | Esomeprazolum | Omeprazole S-form | Perprazole

Show All HSA-registered therapeutic products granted exemption to supply without prescription


  1. Health Science Authority of Singapore – Reclassified POM
  2. Drugbank

HSA-Registered Products Containing Esomeprazole As an oral solid preparation not exceeding 20mg

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This list is not exhaustive. HSA collaborates with Pharmaceurical Society of Singapore (PSS) to review the appropriate use of therapeutic products in the community from time to time. Hence, HSA may enable the supply of a Prescription Only Medicine (POM) by pharmacists without a prescription, upon review that the product can be used in a safe and effective manner under the supervision of a pharmacist. This can be effected through legislative mechanisms in the absence of an application made by the product registrant to reclassify the therapeutic product, subject to to conditions including indication, strength, maximum daily dose, maximum supply quantity, and age restriction.