APO-NITROFURANTOIN TABLET 100mg

Contents

Nitrofurantoin

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

1-((5-nitro-2-furanyl)methylene)amino-2,4-imidazolidenedione | 1-((5-nitrofurfurylidene)amino)hydantoin | 5-Nitrofurantoin | N-(5-Nitrofurfurylidene)-1-aminohydantoin | Nitrofurantoin anhydrous | Nitrofurantoin macrocrystal | Nitrofurantoin macrocrystalline | Nitrofurantoin, macrocrystalline | Nitrofurantoin, macrocrystals | nitrofurantoina | nitrofurantoine | nitrofurantoinum | Nitrofurantoinum anhydrous | Nitrofurantoin |

Description

A bacteriostatic or bactericidal agent depending on the concentration and susceptibility of the infecting organism. Nitrofurantoin is active against some gram positive organisms such as S. aureus, S. epidermidis, S. saprophyticus, Enterococcus faecalis, S. agalactiae, group D streptococci, viridians streptococci and Corynebacterium. Its spectrum of activity against gram negative organisms includes E. coli, Enterobacter, Neisseria, Salmonella and Shigella. It may be used as an alternative to trimethoprim/sulfamethoxazole for treating urinary tract infections though it may be less effective at eradicating vaginal bacteria. May also be used in females as prophylaxis against recurrent cystitis related to coitus. Nitrofurantoin is highly stable to the development of bacterial resistance, a property thought to be due to its multiplicity of mechanisms of action.

Indication

May be used as an alternative in the treatment of urinary tract infections. May be used by females pericoitally for prophylaxis against recurrent cystitis related to coitus.

Mechanism of Action

Nitrofurantoin is activated by bacterial flavoproteins (nitrofuran reductase) to active reduced reactive intermediates that are thought to modulate and damage ribosomal proteins or other macromolecules, especially DNA, causing inhibition of DNA, RNA, protein, and cell wall synthesis. The overall effect is inhibition of bacterial growth or cell death.

Pharmacodynamics

Nitrofurantoin exhibits bacteriostatic or bactericidal effects by inhibiting the synthesis of DNA, RNA, protein and cell wall synthesis.

Pharmacokinetics

Absorption:

Readily absorbed in GI tract primarily in small intestine. Enhanced by food or delayed gastric emptying via enhanced dissolution rate of the drug.

Distribution:

Not Available

Metabolism:

Partially metabolized in liver to aminofurantoin.

Elimination:

Not Available

Half-life

0.3-1 hour

Clearance

Not Available

Toxicity

Acute toxicity may cause vomiting. Adverse effects include nausea and urine discolouration. Rare hepatotoxic and hypersensitivity reactions have occurred. Hemolytic anemia is a risk in patients with G6PD deficiency. Ascending polyneuropathy may occur with prolonged therapy or in patients with low creatinine clearance.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

APO-NITROFURANTOIN TABLET 100mg was registered with Health Science Authority of Singapore by PHARMAFORTE SINGAPORE PTE LTD. It is marketed with the registration number of SIN00290P with effective from 1988-04-21.

This product contains 100mg of Nitrofurantoin in the form of TABLET.

The medicine was manufactured by APOTEX INC in CANADA

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: J01XE01

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