OXY-NASE PAEDIATRIC NASAL SPRAY 0.025% W/V

Oxymetazoline

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

2-(4-Tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline | 3-[(4,5-dihydro-1H-Imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol | 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol | 6-Tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol | Oximetazolinum | Oxymetazolina | Oxymetazolinum | Oxymethazoline | Oxymetozoline | Oxymetazoline |

Description

A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)

Indication

For treatment of nasal congestion and redness associated with minor irritations of the eye

Mechanism of Action

Oxymetazoline is a direct acting sympathomimetic amine, which acts on alpha-adrenergic receptors in the arterioles of the conjunctiva and nasal mucosa. It produces vasoconstriction, resulting in decreased conjunctival congestion in ophthalmic. In nasal it produces constriction, resulting in decreased blood flow and decreased nasal congestion.

Pharmacodynamics

Oxymetazoline a adrenergic alpha-agonists, direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion The sympathomimetic action of oxymetazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (up to 12 hours), gentle and decongesting effect. Oxymetazoline elicits relief of conjunctival hyperemia by causing vasoconstriction of superficial conjunctival blood vessels. The drug's action has been demonstrated in acute allergic conjunctivitis and in chemical (chloride) conjunctivitis.

Pharmacokinetics

Absorption:

Not Available

Distribution:

Not Available

Metabolism:

Not Available

Elimination:

Not Available

Half-life

Not Available

Clearance

Not Available

Toxicity

Not Available

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

OXY-NASE PAEDIATRIC NASAL SPRAY 0.025% W/V was registered with Health Science Authority of Singapore by ZUELLIG PHARMA PTE LTD. It is marketed with the registration number of SIN12295P with effective from 2003-05-14.

This product contains 0.025% w/v of Oxymetazoline in the form of SPRAY.

The medicine was manufactured by HOE PHARMACEUTICALS SDN BHD in MALAYSIA

It is a an Over-the-counter Medicine which can be freely obtained from any retailer

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: R01AA05

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