SIMTEC TABLET 10MG (OTC)

Cetirizine

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

Cetirizin | Cetirizina | Cetirizinum | Cetirizine |

Description

A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. [PubChem]

Indication

For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria

Mechanism of Action

Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The low incidence of sedation can be attributed to reduced penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side chain.

Pharmacodynamics

Cetirizine, the active metabolite of the piperazine H1-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic rhinitis, allergic asthma, physical urticaria, and atopic dermatitis.

Pharmacokinetics

Absorption:

mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine

Distribution:

Not Available

Metabolism:

Not Available

Elimination:

Not Available

Half-life

8.3 hours

Clearance

* 53 mL/min [healthy]

Toxicity

Somnolence (sleepiness or unusual drowsiness), restlessness, irritability

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

SIMTEC TABLET 10MG (OTC) was registered with Health Science Authority of Singapore by CCM PHARMACEUTICALS (S) PTE LTD. It is marketed with the registration number of SIN15142P with effective from 2016-12-21.

This product contains 10mg of Cetirizine in the form of TABLET, FILM-COATED.

The medicine was manufactured by Upha Pharmaceutical Manufacturing (M) Sdn Bhd in MALAYSIA

It is a an Over-the-counter Medicine which can be freely obtained from any retailer

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: R06AE07

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