MYONIT INSTA NITROGLYCERIN SUBLINGUAL TABLETS USP 0.5MG

Nitroglycerin

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

1,2,3-Propanetrioltrinitrate | 1,2,3-Propanetriyl nitrate | Glycerin trinitrate | Glycerol trinitrate | Glycerol, nitric acid triester | Glyceroli trinitratis | Glyceroltrinitrat | Glyceryl trinitrate | Natispray | NG | Nitroglicerina | Nitroglycerin | Nitroglycerine | Nitroglycerol | Nitromed | Propane-1,2,3-triyl trinitrate | Rectogesic | Trinitrine | Trinitroglycerin | Trinitroglycerol | Nitroglycerin |

Description

A volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. [PubChem]

Indication

For the prevention of angina

Mechanism of Action

Similar to other nitrites and organic nitrates, nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Pharmacodynamics

Nitroglycerin, an organic nitrate, is available in many forms as a vasodilator. Nitroglycerin is used in the treatement of angina pectoris and perioperative hypertension, to produce controlled hypotension during surgical procedures, to treat hypertensive emergencies, and to treat congestive heart failure associated with myocardial infarction.

Pharmacokinetics

Absorption:

Not Available

Distribution:

* 3 L/kg

Metabolism:

Hepatic, cytochrome P450 (P450) is a key enzyme of organic nitrate biotransformation

Elimination:

Not Available

Half-life

3 minutes

Clearance

* 1 L/kg/min

Toxicity

Increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

MYONIT INSTA NITROGLYCERIN SUBLINGUAL TABLETS USP 0.5MG was registered with Health Science Authority of Singapore by TRINITY PHARMACEUTICALS & FOOD PTE LTD. It is marketed with the registration number of SIN15702P with effective from 2019-05-31.

This product contains 0.5mg of Nitroglycerin in the form of TABLET.

The medicine was manufactured by Troikaa Pharmaceuticals Limited in INDIA

It is a Pharmacy Only Medicine which can be obtained from a pharmacist at a retail pharmacy.

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: C01DA02

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