APO-ISDN TABLET 10mg

Isosorbide Dinitrate

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

1,4:3,6-Dianhydrosorbitol 2,5-dinitrate | Carvasin | D-Isosorbide dinitrate | Dianhydrosorbitol 2,5-dinitrate | Dinitrate d'isosorbide | Dinitrato de isosorbida | Dinitroisosorbide | Dinitrosorbide | Flindix | ISDN | Isorbid | Isosorbide 2,5-dinitrate | Isosorbide dinitrate | Isosorbidi dinitras | Nitrosorbide | Sorbide nitrate | Sorbidilat | Sorbidnitrate | Isosorbide Dinitrate |

Description

A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. [PubChem]

Indication

For the prevention of angina pectoris due to coronary artery disease.

Mechanism of Action

Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Pharmacodynamics

Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.

Pharmacokinetics

Absorption:

Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.

Distribution:

* 2 to 4 L/kg

Metabolism:

Hepatic

Elimination:

Not Available

Half-life

1 hour

Clearance

Not Available

Toxicity

Symptoms of overdose include reduced cardiac output and hypotension.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

APO-ISDN TABLET 10mg was registered with Health Science Authority of Singapore by PHARMAFORTE SINGAPORE PTE LTD. It is marketed with the registration number of SIN00055P with effective from 1988-02-24.

This product contains 10mg of Isosorbide Dinitrate in the form of TABLET.

The medicine was manufactured by APOTEX INC in CANADA

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: C05AE02

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