BROZIL CAPSULE 300mg

Gemfibrozil

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure | 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure | 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid | Gemfibrozil | Gemfibrozilo | Gemfibrozilum | Gemfibrozil |

Description

A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gemfibrozil increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established. [PubChem]

Indication

For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.

Mechanism of Action

Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. It does so by activating Peroxisome proliferator-activated receptor-alpha (PPARα) 'transcription factor ligand', a receptor that is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.

Pharmacodynamics

Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).

Pharmacokinetics

Absorption:

Well absorbed from gastrointestinal tract (within 1-2 hours).

Distribution:

Not Available

Metabolism:

Hepatic. Gemfibrozil mainly undergoes oxidation of a ring methyl group to successively form a hydroxymethyl and a carboxyl metabolite.

Elimination:

Approximately seventy percent of the administered human dose is excreted in the urine, mostly as the glucuronide conjugate, with less than 2% excreted as unchanged gemfibrozil.

Half-life

1.5 hours

Clearance

Not Available

Toxicity

Oral, mouse: LD50 = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

BROZIL CAPSULE 300mg was registered with Health Science Authority of Singapore by YUNG SHIN PHARMACEUTICAL (SINGAPORE) PTE LTD. It is marketed with the registration number of SIN08467P with effective from 1995-09-12.

This product contains 300mg of Gemfibrozil in the form of TABLET.

The medicine was manufactured by Y S P INDUSTRIES (M) SDN BHD in MALAYSIA

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: C10AB04

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