DEVODIL 50 TABLET 50mg

Sulpiride

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

(+-)-Sulpiride | 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide | Levosulpirida | Levosulpiride | Levosulpiridum | N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide | N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-O-anisamide | Sulpirid | Sulpirida | Sulpiridum | Sulpyrid | Sulpiride |

Description

A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)

Indication

Sulpiride is indicated for the treatment of schizophrenia.

Mechanism of Action

In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.

Pharmacodynamics

Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Other benzamide derivatives include metoclopramide, tiapride, and sultopride.

Pharmacokinetics

Absorption:

Sulpiride is absorbed slowly from the gastrointestinal tract. Its oral bioavailability is only 25 to 35% with marked interindividual differences.

Distribution:

Not Available

Metabolism:

Not Available

Elimination:

Not Available

Half-life

6 to 8 hours

Clearance

Not Available

Toxicity

Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trism. In some cases all the classical symptoms typical of severe Parkinson's Disease may be noted; in others, over-sedation/coma may occur.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

DEVODIL 50 TABLET 50mg was registered with Health Science Authority of Singapore by GOLDPLUS UNIVERSAL PTE LTD. It is marketed with the registration number of SIN01143P with effective from 1988-05-13.

This product contains 50mg of Sulpiride in the form of TABLET.

The medicine was manufactured by REMEDICA LTD in CYPRUS

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: N05AL01

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