KANARB TABLET 120MG

Fimasartan

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

Fimasartan | Fimasartan |

Description

Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Concurrent administration of fimasartan with diuretic hydrochlorothiazide has shown to be safe in clinical trials. Fimasartan was approved for use in South Korea in September 9th, 2010 and is available under the brand name Kanarb through Boryung Pharmaceuticals, who are presently seeking worldwide partnership.

Indication

Used for the treatment of hypertension and heart failure [A20319].

Mechanism of Action

Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at α1-adrenergic receptors [A20319, T28]. It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules [T28]. Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect.

Pharmacodynamics

Fimasartan is a selective angiotensin receptor 1 (AR1) inhibitor [A20319]. It acts to lower blood pressure by inhibiting vasoconstriction

Pharmacokinetics

Absorption:

Tmax is 0.5-1.3 h [A20319].

Distribution:

Not Available

Metabolism:

Not Available

Elimination:

Most is eliminated unchangd in bile with less than 3% in the urine [A20319].

Half-life

The half life of elimination is 7-10 h [A20319].

Clearance

Not Available

Toxicity

Not Available

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

KANARB TABLET 120MG was registered with Health Science Authority of Singapore by ZUELLIG PHARMA PTE LTD. It is marketed with the registration number of SIN15222P with effective from 2017-04-24.

This product contains 120mg of Fimasartan in the form of TABLET.

The medicine was manufactured by BORYUNG PHARMACEUTICAL CO. in KOREA

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Anatomical Therapeutic Chemical (ATC) Classification

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