Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.
Active Ingredient / Synonyms
Fimasartan | Fimasartan |
Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Concurrent administration of fimasartan with diuretic hydrochlorothiazide has shown to be safe in clinical trials. Fimasartan was approved for use in South Korea in September 9th, 2010 and is available under the brand name Kanarb through Boryung Pharmaceuticals, who are presently seeking worldwide partnership.
Used for the treatment of hypertension and heart failure [A20319].
Mechanism of Action
Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at α1-adrenergic receptors [A20319, T28]. It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules [T28]. Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect.
Fimasartan is a selective angiotensin receptor 1 (AR1) inhibitor [A20319]. It acts to lower blood pressure by inhibiting vasoconstriction
Tmax is 0.5-1.3 h [A20319].
Most is eliminated unchangd in bile with less than 3% in the urine [A20319].
The half life of elimination is 7-10 h [A20319].
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