LANOXIN PAEDIATRIC/GERIATRIC ELIXIR 0.05mg/ML

Digoxin

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

Digitalis antitoxin | Digoxin Immune Fab, Ovine | Digoxin-specific Antibody Fragments | Ovine digoxin immune fab | Digoxin Immune Fab (Ovine) |

Description

Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin.

Indication

For treatment of digitoxin overdose or digitalis glycoside toxicity.

Mechanism of Action

Binds excess digoxin or digitoxin molecules circulating in the blood.

Pharmacodynamics

DigiFab binds molecules of digoxin, making them unavailable for binding at their site of action on cells in the body. The Fab fragment-digoxin complex accumulates in the blood, from which it is excreted by the kidney. The net effect is to shift the equilibrium away from binding of digoxin to its receptors in the body, thereby reversing its effects.

Pharmacokinetics

Absorption:

Not Available

Distribution:

* 0.3 L/kg [DigiFab] * 0.4 L/kg [Digibind]

Metabolism:

Not Available

Elimination:

Cumulative urinary excretion of digoxin was comparable for both products and exceeded 40% of the administered dose by 24 hours.

Half-life

15-20 hrs

Clearance

Not Available

Toxicity

Not Available

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

LANOXIN PAEDIATRIC/GERIATRIC ELIXIR 0.05mg/ML was registered with Health Science Authority of Singapore by A. MENARINI SINGAPORE PTE LTD. It is marketed with the registration number of SIN00544P with effective from 1988-04-29.

This product contains 0.05mg/ml of Digoxin in the form of ELIXIR.

The medicine was manufactured by Aspen Bad Oldesloe GmbH in GERMANY

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: C01AA05

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