Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.
Active Ingredient / Synonyms
Digitalis antitoxin | Digoxin Immune Fab, Ovine | Digoxin-specific Antibody Fragments | Ovine digoxin immune fab | Digoxin Immune Fab (Ovine) |
Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin.
For treatment of digitoxin overdose or digitalis glycoside toxicity.
Mechanism of Action
Binds excess digoxin or digitoxin molecules circulating in the blood.
DigiFab binds molecules of digoxin, making them unavailable for binding at their site of action on cells in the body. The Fab fragment-digoxin complex accumulates in the blood, from which it is excreted by the kidney. The net effect is to shift the equilibrium away from binding of digoxin to its receptors in the body, thereby reversing its effects.
* 0.3 L/kg [DigiFab] * 0.4 L/kg [Digibind]
Cumulative urinary excretion of digoxin was comparable for both products and exceeded 40% of the administered dose by 24 hours.
Although best effort has been made to ensure the information provided is correct and updated, users are advised to visit HSA Official website whenever in doubt. Please see Disclaimers.
We welcome all the content error reporting/feedback. Please contact us @ Text Us!