MARTINDALE PHARMA ATROPINE SULFATE SOLUTION FOR INJECTION 600 MCG/ML

Atropine

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

(+-)-Atropine | (+-)-Hyoscyamine | (+,-)-Tropyl tropate | (±)-atropine | (±)-hyoscyamine | (3-Endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate | [(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate | 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate | 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate | Atropin | Atropina | Atropine | Atropinum | dl-Hyoscyamine | dl-tropyltropate | Mydriasine | Tropine tropate | Atropine |

Description

An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae. [PubChem]

Indication

For the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides.

Mechanism of Action

Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects.

Pharmacodynamics

Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.

Pharmacokinetics

Absorption:

Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.

Distribution:

Not Available

Metabolism:

Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver. From 13 to 50% is excreted unchanged in the urine.

Elimination:

Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver; from 13 to 50% is excreted unchanged in the urine.

Half-life

3.0 ± 0.9 hours in adults. The half-life of atropine is slightly shorter (approximately 20 minutes) in females than males.

Clearance

Not Available

Toxicity

Oral, mouse: LD50 = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

MARTINDALE PHARMA ATROPINE SULFATE SOLUTION FOR INJECTION 600 MCG/ML was registered with Health Science Authority of Singapore by DKSH SINGAPORE PTE LTD. It is marketed with the registration number of SIN15611P with effective from 2019-01-11.

This product contains 600 mcg/ml of Atropine in the form of INJECTION, SOLUTION.

The medicine was manufactured by Macarthys Laboratories Ltd T/A Martindale Pharma in UNITED KINGDOM

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Anatomical Therapeutic Chemical (ATC) Classification

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