PENTHROX INHALATION LIQUID 99.9%

Methoxyflurane

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

Methoflurane | Methoxyfluoran | Methoxyfluran | Methoxyfluranum | Methyl 1,1-difluoro-2,2-dichloroethyl ether | Metoxiflurano | Methoxyflurane |

Description

An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)

Indication

For use in the induction and maintenance of general anesthesia

Mechanism of Action

Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.

Pharmacodynamics

Methoxyflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.

Pharmacokinetics

Absorption:

Not Available

Distribution:

Not Available

Metabolism:

Hepatic.

Elimination:

Not Available

Half-life

Not Available

Clearance

Not Available

Toxicity

LD50=3600 mg/kg (Orally in rats). Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

PENTHROX INHALATION LIQUID 99.9% was registered with Health Science Authority of Singapore by LINK HEALTHCARE SINGAPORE PTE LTD. It is marketed with the registration number of SIN14854P with effective from 2015-09-21.

This product contains 99.9 percent of Methoxyflurane in the form of INHALANT.

The medicine was manufactured by Medical Developments International LTD (MDI) in AUSTRALIA

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: N02BG09

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