PROCARDIN 75 TABLET 75mg

Dipyridamole

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

Cleridium 150 | Curantyl | Dipiridamol | Dipyridamine | Dipyridamolum | Dipyudamine | Dypyridamol | Persantin | Dipyridamole |

Description

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)

Indication

For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.

Mechanism of Action

Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

Pharmacodynamics

Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis.

Pharmacokinetics

Absorption:

70%

Distribution:

* 1 to 2.5 L/kg

Metabolism:

hepatic

Elimination:

Dipyridamole is metabolized in the liver to the glucuronic acid conjugate and excreted with the bile.

Half-life

40 minutes

Clearance

* 2.3-3.5 mL/min/kg

Toxicity

Hypotension, if it occurs, is likely to be of short duration, but a vasopressor drug may be used if necessary. The oral LD50 in rats is greater than 6,000 mg/kg while in the dogs, the oral LD50 is approximately 400 mg/kg. LD50=8.4g/kg (orally in rat)

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

PROCARDIN 75 TABLET 75mg was registered with Health Science Authority of Singapore by MEDOCHEMIE SINGAPORE PTE LTD. It is marketed with the registration number of SIN00263P with effective from 1988-06-04.

This product contains 75mg of Dipyridamole in the form of TABLET, FILM-COATED.

The medicine was manufactured by MEDOCHEMIE LTD in CYPRUS

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: B01AC07

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