TROBICIN FOR INJECTION 2g/VIAL

Spectinomycin

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

Actinospectacina | Espectinomicina | SCM | Spectinomicina | Spectinomycine | Spectinomycinum | Spectinomycin |

Description

An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.

Indication

For use in the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of Neisseria gonorrhoeae.

Mechanism of Action

Spectinomycin is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. It is bactericidal in its action.

Pharmacodynamics

Spectinomycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure.

Pharmacokinetics

Absorption:

Rapidly and almost completely absorbed after intramuscular injection.

Distribution:

Not Available

Metabolism:

Not Available

Elimination:

Not Available

Half-life

1 to 3 hours in patients with normal renal function and 10 to 30 hours in patients with impaired renal function with a creatinine clearance < 20 mL per minute.

Clearance

Not Available

Toxicity

Acute oral toxicity (LD50): >5000 mg/kg [Rat]. Information on overdosage in humans is not available.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

TROBICIN FOR INJECTION 2g/VIAL was registered with Health Science Authority of Singapore by PFIZER PTE LTD. It is marketed with the registration number of SIN01056P with effective from 1988-12-05.

This product contains 2g/vial of Spectinomycin in the form of INJECTION, POWDER, FOR SOLUTION.

The medicine was manufactured by PFIZER MANUFACTURING BELGIUM NV (Diluent) Panpharma (Spectinomycin Hydrochloride vial) in BELGIUM, and in FRANCE

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: J01XX04

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44APO-DIAZEPAM TABLET 5mgDiazepamPOMPHARMAFORTE SINGAPORE PTE LTDActive
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678BANEOCIN POWDERBacitracin|NeomycinPOMNOVARTIS (SINGAPORE) PTE LTDActive