EXODIN TABLET 180MG

Fexofenadine

Source of information: Drugbank (External Link). Last updated on: 3rd July 18
*Trade Name used in the content below may not be the same as the HSA-registered product.

Active Ingredient / Synonyms

4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid | Carboxyterfenadine | Fexofenadine | Terfenadine acid metabolite | Terfenadine carboxylate | Terfenadine-COOH | Fexofenadine |

Description

Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.

Indication

For management of Seasonal allergic rhinitis

Mechanism of Action

Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Fexofenadine exhibits no anticholinergic, antidopaminergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects.

Pharmacodynamics

Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential of terfenadine, since it does not block the potassium channel involved in repolarization of cardiac cells.

Pharmacokinetics

Absorption:

33%

Distribution:

Not Available

Metabolism:

Approximately 5% of the total dose is metabolized, by cytochrome P450 3A4 and by intestinal microflora.

Elimination:

Not Available

Half-life

14.4 hours

Clearance

Not Available

Toxicity

Side effects include dizziness, drowsiness, and dry mouth.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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Approval Information

EXODIN TABLET 180MG was registered with Health Science Authority of Singapore by PHARMAZEN MEDICALS PTE LTD. It is marketed with the registration number of SIN14591P with effective from 2014-08-18.

This product contains 180mg of Fexofenadine in the form of TABLET, FILM-COATED.

The medicine was manufactured by Medreich LTD in INDIA

It is a has been granted the exemptions for supply without a presciption if it met certain criteria.

Reclassified Info

Anatomical Therapeutic Chemical (ATC) Classification

ATC Code: R06AX26

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