Product InformationRegistration Status: Active
FEXODIN FILM COATED TABLET 120MG is approved to be sold in Singapore with effective from 2019-06-12. It is marketed by PHARMAZEN MEDICALS PTE LTD, with the registration number of SIN15714P.
This product contains Fexofenadine 120mg in the form of TABLET, FILM COATED. It is approved for Not Available use.
This product is manufactured by Medreich Limited in INDIA.
It is an Over-the-counter Medicine that can be freely obtained from any retailer
Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.
For management of Seasonal allergic rhinitis
Mechanism of Action
Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Fexofenadine exhibits no anticholinergic, antidopaminergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects.
- Approximately 5% of the total dose is metabolized, by cytochrome P450 3A4 and by intestinal microflora.
Side effects include dizziness, drowsiness, and dry mouth.
4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid | Carboxyterfenadine | Fexofenadine | Terfenadine acid metabolite | Terfenadine carboxylate | Terfenadine-COOH | Fexofenadine |
Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.