Approval Information

BICALOX TABLET 50MG was registered with Health Science Authority of Singapore by GOOD PHARMACEUTICAL PTE LTD. It is marketed with the registration number of SIN14145P with effective from 2012-08-05.

This product contains 50MG of Bicalutamide in the form of TABLET, FILM-COATED.

The medicine was manufactured by DOUGLAS MANUFACTURING LTD in NEW ZEALAND

It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor or dentist.



Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is a racemic mixture consisting of equal proportions of enantiomers (R)-bicalutamide and (S)-bicalutamide. Bicalutamide binds to the androgen receptor.


For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.

Mechanism of Action

Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue.



Bicalutamide is well-absorbed following oral administration, although the absolute bioavailability is unknown.



Bicalutamide undergoes stereo specific metabolism. The S (inactive) isomer is metabolized primarily by glucuronidation. The R (active) isomer also undergoes glucuronidation but is predominantly oxidized to an inactive metabolite followed by glucuronidation.



* Apparent oral cl=0.32 L/h [Normal Males]

Active Ingredient/Synonyms

Bicalutamida | Bicalutamide | Bicalutamidum | Bicalutamide |

Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.


  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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