|Eligible Active Ingredient:
||Adapalene. As a topical preparation not exceeding 0.1%
|With Effective From:
||Treatment of acne vulgaris
|Maximum Daily Dose:
||Apply to the affected areas once daily
|Maximum Supply per Transaction:
|Minimum Age of User:
|Patient Information Leaflet from HSA/PSS:
||Download PIL (Link to HSA website)
Mechanism of Action of Adapalene
Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and retinoid X receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.
Additional Information of Adapalene
||Anti-Acne Preparations For Topical Use
||Retinoids For Topical Use In Acne
||6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid | Adaferin | Adapaleno | Adapalenum | Differine
Show All HSA-registered therapeutic products granted exemption to supply without prescription
- Health Science Authority of Singapore – Reclassified POM
HSA-Registered Products Containing Adapalene As a topical preparation not exceeding 0.1%
wpDataTable with provided ID not found!
This list is not exhaustive. HSA collaborates with Pharmaceurical Society of Singapore (PSS) to review the appropriate use of therapeutic products in the community from time to time. Hence, HSA may enable the supply of a Prescription Only Medicine (POM) by pharmacists without a prescription, upon review that the product can be used in a safe and effective manner under the supervision of a pharmacist. This can be effected through legislative mechanisms in the absence of an application made by the product registrant to reclassify the therapeutic product, subject to to conditions including indication, strength, maximum daily dose, maximum supply quantity, and age restriction.