|Eligible Active Ingredient:
||Ibuprofen Syrup. As an oral liquid preparation not more than 100mg/5ml
|With Effective From:
||Reduction of fever, including postimmunisation pyrexia, and relief of mild to moderate pain such as sore throat, teething pain and toothache, earache, minor aches and sprains
|Maximum Daily Dose:
||30 mg/kg, up to a maximum of 1.2g
|Maximum Supply per Transaction:
||3 days. The lowest effective dose should be used for the shortest duration necessary to relieve symptoms
|Minimum Age of User:
|Patient Information Leaflet from HSA/PSS:
||Download PIL (Link to HSA website)
Mechanism of Action of Ibuprofen Syrup
The exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacological effects are believed to be due to inhibition cylooxygenase-2 (COX-2) which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Inhibition of COX-1 is thought to cause some of the side effects of ibuprofen including GI ulceration. Ibuprofen is administered as a racemic mixture. The R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo. The S-enantiomer is believed to be the more pharmacologically active enantiomer.
Additional Information of Ibuprofen Syrup
||Antiinflammatory And Antirheumatic Products, Non-Steroids
||Antiinflammatory And Antirheumatic Products
||Propionic Acid Derivatives
||(¬±)-2-(p-isobutylphenyl)propionic acid | (¬±)-ibuprofen | (¬±)-p-isobutylhydratropic acid | (¬±)-Œ±-methyl-4-(2-methylpropyl)benzeneacetic acid | (4-isobutylphenyl)-Œ±-methylacetic acid | (RS)-ibuprofen | 2-(4-isobutylphenyl)propanoic acid | 4-isobutylhydratropic acid | Ibuprophen | Œ±-(4-isobutylphenyl)propionic acid | Œ±-(p-isobutylphenyl)propionic acid
Show All HSA-registered therapeutic products granted exemption to supply without prescription
- Health Science Authority of Singapore – Reclassified POM
HSA-Registered Products Containing Ibuprofen Syrup As an oral liquid preparation not more than 100mg/5ml
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This list is not exhaustive. HSA collaborates with Pharmaceurical Society of Singapore (PSS) to review the appropriate use of therapeutic products in the community from time to time. Hence, HSA may enable the supply of a Prescription Only Medicine (POM) by pharmacists without a prescription, upon review that the product can be used in a safe and effective manner under the supervision of a pharmacist. This can be effected through legislative mechanisms in the absence of an application made by the product registrant to reclassify the therapeutic product, subject to to conditions including indication, strength, maximum daily dose, maximum supply quantity, and age restriction.