HSA Reclassified Drug | Exemptions For Supply of Ruscogenins and trimebutine cream Without Prescription


Eligible Active Ingredient: Ruscogenins and trimebutine. As a rectal cream not exceeding 0.5g/5.8g per 100g
With Effective From: 1-Dec-16
Indication Permitted: For the symptomatic relief of external and internal haemorrhoids, anal pruritis, anal fissure
Maximum Daily Dose: One or two applications per day
Maximum Supply per Transaction: 20g
Minimum Age of User: 18 years
Patient Information Leaflet from HSA/PSS: Download PIL (Link to HSA website)

Mechanism of Action of Ruscogenins and trimebutine

Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, omeprazole blocks the final step in acid production, thus reducing gastric acidity.

Additional Information of Ruscogenins and trimebutine

Pharmacology Class: Agents For Treatment Of Hemorrhoids And Anal Fissures For Topical Use
Therapeutic Class: Vasoprotectives
Chemical Class: Corticosteroids
Synonyms: OMEP | Omeprazol | Omeprazolum

Show All HSA-registered therapeutic products granted exemption to supply without prescription


  1. Health Science Authority of Singapore – Reclassified POM
  2. Drugbank

HSA-Registered Products Containing Ruscogenins and trimebutine As a rectal cream not exceeding 0.5g/5.8g per 100g

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This list is not exhaustive. HSA collaborates with Pharmaceurical Society of Singapore (PSS) to review the appropriate use of therapeutic products in the community from time to time. Hence, HSA may enable the supply of a Prescription Only Medicine (POM) by pharmacists without a prescription, upon review that the product can be used in a safe and effective manner under the supervision of a pharmacist. This can be effected through legislative mechanisms in the absence of an application made by the product registrant to reclassify the therapeutic product, subject to to conditions including indication, strength, maximum daily dose, maximum supply quantity, and age restriction.