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APO-TRIFLUOPERAZINE TABLET 5mg

Product Information

Registration Status: Active

SIN00289P

APO-TRIFLUOPERAZINE TABLET 5mg is approved to be sold in Singapore with effective from 1988-04-21. It is marketed by PHARMAFORTE SINGAPORE PTE LTD, with the registration number of SIN00289P.

This product contains Trifluoperazine 5mg in the form of TABLET, FILM-COATED. It is approved for ORAL use.

This product is manufactured by APOTEX INC in CANADA.

It is a Prescription Only Medicine that can only be obtained from a doctor or a dentist, or a pharmacist with a prescription from a Singapore-registered doctor or dentist.

Product Reference
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Description

A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. [PubChem]

Indication

For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.

Mechanism of Action

Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Toxicity

Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.

Active Ingredient/Synonyms

10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine | 10-[3-(4-METHYL-piperazin-1-yl)-propyl]-2-trifluoromethyl-10H-phenothiazine | Trifluoperazina | Trifluoperazine | Trifluoperazinum | Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine | Trifluoroperazine | Trifluperazine | Trifluoperazine |


Source of information: Drugbank (External Link). Last updated on: 3rd July 18. *Trade Name used in the content below may not be the same as the HSA-registered product.

References

  1. Health Science Authority of Singapore - Reclassified POM
  2. Drugbank

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